Colon Cancer Part 1: Honest doctor, shockingly honest advice!

Almost every day cancer patients write or come to me for help. For the past few weeks, I saw cases after cases of colon cancer. The cancer cases come in a non-random, wave-like patent. It looks like these past weeks is a “colon cancer season.” Indeed I find this strange and unexplainable.

I have already written two cases of colorectal cancer earlier! And now I am going to share a few more cases with you.

Case of: Honest doctor, shockingly honest advice!

SE is a 62-year-old Malaysian lady. About three months ago she passed out blood in her stools. She went to private hospital and did an endoscopy followed by CT scan of her abdomen and pelvis.

CT scan showed a 8 x 11 x 14 mm polypoidal mass on the anterior wall of the mid sigmoid and a 18 cm tumour from the anal verge. A biopsy confirmed an invasive moderately differentiated adenocarcinoma.

The doctor suggested surgery. According to SE’s son, the whole treatment would cost about RM 60,000 (if done in a private hospital). SE has no money and she is not covered by any health insurance. SE was subsequently referred to a “government-sponsored hospital” for further treatment.

SE underwent surgery in December 2019. One of the 11 lymph nodes removed was involved. But the cancer has not spread to any other organs. SE was told it was a Stage 3 cancer.

In all, the operation in this “government-sponsored hospital” cost about RM3,000 (against RM60K in a private hospital).

SE was told to undergo follow-up chemotherapy. Since SE did not speak English, the doctor wrote his recommendation on a piece of paper (see below). He suggested that SE go home and discuss this matter with her family members.

I was indeed shocked to read this note from her doctor (of thisĀ  “government-sponsored hospital”). My first reaction was to SALUTE this honest doctor! Thank you Doc., for being very honest and up front with your patient.

Let us read the note (translated) carefully.

Watch this video:

SE and her family decided not to undergo chemotherapy!

Comments

Let me ask you this question: Given that to do chemo or not to do chemo makes no difference! And 5 patients out of 100 would benefit from the chemo-treatment. What would you do if you were in SE’s situation?

It looks like, if doctors were to give their patients honest information (perhaps based on their own experiences and reading of medical journals) most patients would run away from chemotherapy. If this happens, cancer industry is no more a lucrative billion-dollar industry.

Many of you may want to dispute what SE’s oncologists said! How could it be — only 5 percent benefit only? How could it be, to do or not to do chemo is about the same? If don’t want to do chemo also, ok! What kind of oncologist is that? My answer is: This is the very honest kind of oncologist. Don’t get angry at him. What he said is very true. Instead let us salute him for being honest. The world needs such doctors!

Let me ask you to reflect on the quotations below:

Two more postings to come:

Colon Cancer Part 2: What if no chemo?

Colon Cancer Part 3: Let the truth be told – shocking outcome after surgery and chemo..

 

 

 

The Cancer Industry: Hype vs. Reality

Cancer medicine generates enormous revenues but marginal benefits for patients

BIG PROBLEM, BIG BUSINESS, BIG HYPE

ByĀ John HorganĀ onĀ 12 February 2020

Source: Ā https://blogs.scientificamerican.com/cross-check/the-cancer-industry-hype-vs-reality/

Basic Facts

  • Cancer is the second most lethal disease in the U.S., behind only heart disease.
  • More than 1.7 million Americans were diagnosed with cancer in 2018, and more than 600,000 died.
  • Almost four out of ten people will be diagnosed in their lifetime.

Big Business

  • Cancer has spawned a huge industrial complex involving government agencies, pharmaceutical and biomedical firms, hospitals and clinics, universities, professional societies, nonprofit foundations and media.
  • Total research spending since Richard Nixon declared a ā€œwar on cancerā€ in 1971 exceeds a quarter trillion dollars.

Big Bluff

  • Cancer-industry boosters claim that investments in research, testing and treatment have led to ā€œincredible progressā€ and millions of ā€œcancer deaths averted,ā€
  • Cancer experts and the media often describe new treatments with terms such as ā€œbreakthrough,ā€ ā€œgame changer,ā€ ā€œmiracle,ā€ ā€œcure,ā€ ā€œhome run,ā€ ā€œrevolutionary,ā€ ā€œtransformative,ā€ ā€œlife saver,ā€ ā€œgroundbreakingā€ and ā€œmarvel.ā€
  • There are 1,200 accredited cancer centers in the U.S. They spent $173 million on television and magazine ads directed at the public in 2014.
  • 43 of the 48 top spenders ā€œdeceptively promot[ed] atypical patient experiences through the use of powerful testimonials.ā€Ā A 2014 studyconcluded that cancer centersĀ ā€œfrequently promote cancer therapy with emotional appeals that evoke hope and fear while rarely providing information about risks, benefits, costs, or insurance availability.ā€

Little Net Progress After 90 Years

Whatā€™s the reality behind the hype? Ā Azra Raza, an oncologist at Columbia, in her bookĀ The First Cell: And the Costs of Pursuing Cancer to the Last wrote:

  • No one is winning the war on cancer, Claims of progress are mostly hype, the same rhetoric from the same self-important voices for the past half century.Ā 

Azra Raza, an oncologist at Columbia. SheĀ  has watched too many people die from cancer — her patients and her husband, also a cancer specialist.

New Treatments Yield Small Benefits, Big Costs

  • Pharmaceutical companies keep bringing new drugs to market. But … 72 new anticancer drugs approved by the FDA between 2004 and 2014 prolonged survival for an average of 2.1 months.
  • Most cancer drug approvals have not been shown to, or do not, improve clinically relevant end points, including survival and quality of life … the FDA may be approving many costly, toxic drugs that do not improve overall survival.
  • Costs of cancer treatments have vastly outpaced inflation, and new drugsĀ are estimated to coston average more than $100,000/year.
  • More than 40 percent of people diagnosed with cancer lose their life savings within 2 years.

Immunotherapy

Immune therapies, which seek to stimulate immune responses to cancer, have generated enormous excitement.

Drugs firms aggressively market immune therapies, and patients are ā€œpushing hard to try them, even when there is little to no evidence the drugs will work for their particular cancer.ā€

Oncologists Nathan Gay and Vinay Prasad estimated that fewer than 10 percent of cancer patients can benefit from immune therapies, and that is a ā€œbest-case scenario”.

Immune therapiesĀ trigger severe side effects, and they are also extremely expensive, costing hundreds of thousands of dollars a year.

Subsequent hospital stays and supportive care can drive the total costs to a million dollars or more … If widely prescribed, immune therapies could bankrupt the American health-care system.

Corruption In The Cancer Industry

The American approach (to cancer treatment) fosters corruption.

Many cancer specialists accept payments from firms whose drugs they prescribe. This practice leads us to celebrate marginal drugs as if they were game-changers. It leads experts to ignore or downplay flaws and deficits in cancer clinical trials. It keeps doctors silent about the crushing price of cancer medicines.

Top officials at Sloan Kettering Cancer Center ā€œrepeatedly violated policies on financial conflicts of interest, fostering a culture in which profits appeared to take precedence over research and patient care.

 

Ā 

 

Diet for Cancer – The most sore and controversial aspect of cancer healing

When I first started CA Care, one of the thing I did was to read as many books as I can get hold on regarding the diet which are suitable for cancer patients. From my reading, I came to realize and firmly believe that diet plays an important role in the healing of cancer.

I also took to heart what some doctors themselves said about diet. Reflect on these:

I have come to the conclusion that there is no two ways about it — cancer patients cannot eat what they like! This is the very opposite of what patients are being told by their doctors! No need to “pantang”. You can eat what you like. When the cancer recurred after an apparently “successful” treatment, one doctor told his patient – This has nothing to do with your diet! It is just your luck. Fated ! Wow, scientific medicine believes in “karma” too! Wonderful world indeed.

Diet – quackery?

From my many years of taking care of cancer patients, I must say that keeping to a good diet is the most sore point among cancer patients. Many patients do not want to take care of their diet. They want to eat what they like. They say – Cannot this, cannot eat that. If I cannot eat what I like, then life is not worth living.

Yes, I have begun to accept this reality. So this is my advice: There is no use coming to see us if you don’t want to take care of your diet. Healing of cancer is about you. Do you want to really help yourself or not? Believing that by taking “magic” supplements, herbs, etc. or undergoing surgery, chemotherapy or/and radiotherapy would “cure” your cancer is faulty thinking!

Most patients know that doctors generally do not believe in “diet” – they tell their patients to eat anything they like. Well, I don’t intend to argue with them on this topic. Those who believe, let them believe; those who don’t believe let them be. I have taken heed of this advice below!

Confusing world of nutrition: What the alternative healers say!

The responsibility of using diet as a way to help cancer patients generally fall on the shoulders of the alternative healers — the so called snake oil peddlers! Or the quacks.

When I first started reading books on dietary recommendation for cancer, I must say I was just frustrated. There are so many different and and contradicting views. This confused me. Everyone wants to be a hero and everyone claims that their dietary regime is magical and can “cure” cancer. Sad world indeed.

Here are some the dietary regimes that are being championed:

  • High protein diet. Eat cancer-fighting foodssuch as chicken, fish, lean beef, Greek yogurt, beans, lentils, peas, soy foods, eggs and nuts. Did they say we cannot eat rice or carbohydrate?
  • Macrobiotic diet. The formula is: Take 40% to 60% whole grains; 20% to 30% vegetables, including sea vegetables’ % to 10% legumes, including beans, lentils and soy foods and a small amounts of fruit, fish, seeds and nuts.
  • Gerson Therapy. Drink lots of crushed and juiced fruit and vegetables daily. Consume the juiced and crushed food hourly, for at least 13 hours every day. Take multiple dietary supplements daily including potassium, vitamin B12, pancreatic enzymes and ā€œthyroid-supportā€ products, etc.
  • Budwig Diet. Consume a blend of flaxseed oil and cottage cheese every day. The program also includes juicing and other whole plant foods. The diet omits pork, shellfish, animal fats, refined sugar, alcohol, caffeine, processed foods and preservatives, refined flour and grains, hydrogenated oils and fats and all dairy, except cottage cheese.
  • Keto diet. This diet recommends a very high-fat, low-protein, extremely low-carbohydrate eating plan. Your diet should consist of 80% to 90% fat and 8% to 15% protein. The remaining calories can come from carbohydrates.

There are many more diet recommendations for cancer patients. You just need to sit in front of your computer if you want to learn more.

Grape therapy by Dr. Johanna Brandt

Ā Wheat Grass Therapy and Ā Hippocrates Diet,

Blood Diet Type by Dr. Peter D’Adamo,

Dr. Moerman’s Anti-cancer Diet,

The Dries Cancer Diet,

The Paleo Diet,

Ā South Beach Diet,

Atkins Diet. etc.

Although these diets appear appealing to some people, I am afraid cancer patients do not have the time and luxury to try out or experiment for themselves to know if such diet does or does not help them. Because of that some patients come to me asking for my opinion on this and that diet. My response to them are as follows:

  1. I do not believe that diet by itself can cure your cancer. Help yes, but not cure.
  2. Use your head to decide what is good for you.

One lady started to drink 15 to 20 glass of juice per day and she fainted. After all she has never done such thing before. Another lady had severe diarrhoea after taking so much juices.

I am not saying juices are not good for you but I am also telling you NOT to drink that much each day. Use your common sense.

  1. Learn to live a healthy life by looking back at what your fore fathers ate and did. If they had been eating rice all their lives, I just wonder why do people say — Now you need to eat a lot of meat and fat? Do you see any logic with such advice?

I believe we Asians need to learn from the wisdom of our forefathers in trying to find solution to our health problems.

  1. Today we are facing all kinds of serious chronic health problems — obesity, heart problems, all kinds of cancer, etc. Why the sudden explosion of such cases — is it not due to eating non-natural, GMO modified, ultra-refined, junk food, besides alcohol, tobacco, etc. ?

The most important point is: whatever conclusions we arrive at — what to eat and what not to eat — it must be based on scientific study and scientific data. How many patients are being helped or benefited from whatever fancy diet that is proposed. Where is the solid, results to prove the claim?

Over the years of reading books by many authors about diet, I want to say that Professor T. Colin Campbell has earned my highest respect. The conclusions derived from his years of research make a lot of sense.

Professor T. Colin Campbell was a professor at Cornell University, USA. He wrote the book, The China Study. It is 417 pages thick and is packed with nutrition facts and research statistics. In this age of Whatsapp, Twitter, etc not many people like to read such thick, scientific book! Ā They prefer to be led by the nose by certain “guru” or self-proclaimed nutritional expert.

I am not asking you to read The China Study if you have no time or no desire to do so. But at least you can read the summary of the book below if you want to get well or stay healthy.

I outlined some of the important information obtained from three articles which I read in the internet.

https://www.wellandgood.com/good-food/china-study-cheat-sheet-10-things-you-need-to-know/

https://www.allencheng.com/the-china-study-summary-t-colin-campbell/

https://medium.com/karlbooklover/the-china-study-summary-3c1d9b2a682d

Ā Professor Campbell’s The China Study and his research

The China StudyĀ is based, in part, on one of the most extensive nutrition studies ever done. For the project, Professor Colin Campbellā€™s Cornell team partnered with Oxford University and the Chinese Academy of Preventive Medicine to study the diets, lifestyles, and diseases of inhabitants of rural China. The data collected spanned over 20 years.

The study they created included 367 variables, 65 counties in China, and 6,500 adults (who completed questionnaires, blood tests, etc.). ā€œWhen we were done, we had more than 8,000 statistically significant associations between lifestyle, diet, and disease variables.ā€

What sets the whole foods, plant-based diet that Professor Campbell advocated apart from the various dietary fads I listed aboveĀ  is the extensive research behind it. The evidence is compelling and the message clear.

InĀ The China Study, ProfessorĀ  T. Colin Campbell, PhD, and his son, Thomas M. Campbell II, MD, discuss and analyze the results from the study (and other influential nutrition research) and recommend their protocol for the best diet for long-term health.

Here are what Professor Campbell want all of us to know:

  1. Eating plant foods may be one of the leading determiners of health in rural China, and eating animal protein may be one of the leading causes of disease in the Western world.

People who ate the most animal-based foods got the most chronic disease. People who ate the most plant-based foods were the healthiest.

  • Eat plant-based proteins.These come in the forms of fruits, vegetables, and whole grains. Eat as much as you want, as long as what youā€™re eating is plant-based and unrefined.
  • Eat a variety of fruits and vegetablesto increase your antioxidant intake and protect yourself against free radicals. This also ensures youā€™re getting all the essential amino acids for healthy growth and increased strength.
  1. Animal foods lead to disease; plant foods prevent and treat it.Ā 
  • Avoid animal-based proteinsto decrease your risk of heart disease, cancer, diabetes, etc.
  • Animal-based proteins are those in meat, fish, eggs, and dairy. In hundreds of studies, eggs, cheese, milk, and meat have all been shown to increase your risk of everything from obesity and diabetes to cancer and autoimmune diseases.
  1. Animal protein promotes the growth of cancer. Professor Campbell grew up on a dairy farm, so he regularly enjoyed a wholesome glass of milk. Not anymore.
  • The growth of cancer cells can be turned on and off by raising and lowering doses of casein, the main protein found in cowā€™s milk.
  • Reduce your intake of milk productsā€”casein has been shown to increase cholesterol and promote tumor growth.

4.You donā€™t need to eat meat.Ā  There are virtually no nutrients in animal-based foods that are not better provided by plants.

  • Almost any nutrient you can find in animal-based foods, you can find in a healthier form in plant-based foods.
  • Plant-based foods have a much better nutrient profile than animal-based foods. Plant-based foods have a lot more antioxidant, fiber, and mineral content than animal foods.
  1. Eat a high-carb, rather than a low-carb diet.But make sure youā€™re getting your carbohydrates from whole, not refined, foods. Highly-processed, refined carbohydrates are bad for you.
  2. Eating high-fat, high protein and low carbohydrates could have dangerous side effects for long-term health.Ā 
  • Eliminate saturated fat from your diet.Saturated fats are generally found in animal products. Foods with especially high amounts include beef, pork, poultry skins, hot dogs, bacon, lunch meats, butter, lard, high-fat dairy, and fried foods.
  • Get less than 10% of your calories from fatto prevent or treat heart disease.
  1. You donā€™t have to tailor your diet for specific health benefits.Ā  Nutrition that is truly beneficial for one chronic disease will support health across the board. Nutrition which prevent disease can also halt or reverse disease. For example:
  • Heart disease can be reversed through nutrition.Ā Caldwell B. Esselstyn, Jr., MD, a physician and researcher at the best cardiac center in the country, The Cleveland Clinic, treated 18 patients with established coronary disease using a whole food, plant-based diet. Not only did the intervention stop the progression of the disease, but 70 percent of the patients saw an opening of their clogged arteries.
  • Itā€™s not just cancer and heart disease that respond to a whole food, plant-based diet. Research showed it may also help protect you from diabetes, obesity, autoimmune diseases, bone, kidney, eye, and brain diseases.

Understanding the Principles of the Whole Foods, Plant-Based Diet

  1. Various nutrients work together to achieve health. No single nutrient is responsible for good health. What matters most is how the various nutrients in foods work together to create change in the body and maintain good health. This is why eating whole foods rather than taking nutrition supplements is so important.
  2. Avoid supplements. Exceptions are for vitamin B12, and vitamin D (if you live in an area with limited sunlight). Our body needs a wide variety of complex nutrients. Instead of focusing on individual nutrients we should go for variety. Vitamin supplements cannot replace good whole foods. Isolated nutrients are a waste of money and some of them even are potentially dangerous as they can cause an intoxication.

So get your nutrients from food, not pills. The way nutrients function in the body is complex, and itā€™s not always clear whether certain benefits come from a single nutrient or from the whole food, so youā€™re better off eating the whole food.

  1. Good nutrition can counter the negative effects of carcinogens. We think that carcinogens cause cancer, but, carcinogens likely need to be activated to do harm. Theyā€™re often activated by diets high in animal protein. Conversely, antioxidant-rich plant foods can diminish the potency of carcinogens.
  2. Nutrition that prevents one disease is probably beneficial for health in general. Whole, plant foods seem to reduce risk across the board. Therefore, a diet thatā€™s good for your heart is also good for your brain, liver, kidneys, and nervous system.
  3. Good nutrition works holistically with physical activity, mental and emotional health, and our environment.
  • Positive lifestyle changes work together and build off one another to promote health. For example, eating well gives us more energy. Having more energy makes it easier to exercise more. Exercising more promotes mental and emotional health. When weā€™re in a better mood, we eat healthier meals, and the cycle continues.
  • Exercise 15-45 minutes a day, every day.

Our advice to cancer patients who come to seek our helpĀ 

  • Take care of your diet. Don’t take meat (or anything that walks!); no oil (exception: coconut or olive oil); no refined sugars, use sea salt instead of the processed fine, table salt. We don’t give our diet therapy any fanciful nameĀ  – there is no need to create a cult or fad!
  • Our mission is to make you well by asking you to eat fresh (unprocessed), healthy plant-based food.
  • Do patients benefit by following our diet recommendation. YES, definitely! Patients who started to eat what they like suffered badly even after being well for a while. Click on this link to learn more about this: https://cancercaremalaysia.com/category/diet-nutrition/
  • Whether you wish to follow our dietary recommendation or not is entirely up to you! Health is your responsibility. To get well, to stay healthy or to remain ill is entirely your choice.

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Beware: Americans are the sickest and most overweight people in the world! Why? No doubt it is due to the SAD diet – the Standard American Diet. In America everyone wants to find a “magic” diet to make them well while they gobble down alcohol, soda, junky fast food, steak, etc. etc. So you see, there is opportunity to make easy money if you can come up with a “nice sounding” formula to make people healthy instantly!Ā 

The goal of the ā€œhealthā€ industry is to make a profit, not to make us healthy.

Part of the problem is that genuine, useful research is buried beneath fad diets, miracle pills, and marketing propaganda. The people and companies who give us health advice are often also the ones who profit from our diseases.

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Watch this video.

Why is the Science of Nutrition Ignored in Medicine? by Professor Colin Campbell

https://www.youtube.com/watch?v=tmWoWOM16uE

 

 

 

 

Chemotherapy Spreads Cancer

Chemotherapy spreads cancer! Ā You get the message? Is it a joke of some kind? And in this present age, is it fake news? Many people would argue — if chemo is that bad as implied by the title of this article, why then governments all over the world endorse such treatment? Chemotherapy for cancer is supposed to be proven and scientific, right? Why do doctors give chemo to their patients if it is that bad? Do I need to answer such questions?

Here are some facts presented by scientists.

On 30 December 2018, a group of medical researchers from the School of Life Sciences, Ɖcole Polytechnique FĆ©dĆ©rale de Lausanne (EPFL), Lausanne, Switzerland; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA and Department of Ā Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, NY, USA, wrote an article in the Nature Cell Biology journal: Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models https://www.nature.com/articles/s41556-018-0256-3.

Below is the abstract of this research report:

  • Primary tumours release extracellular vesicles (EVs), that can facilitate the seeding and growth of metastatic cancer cells in distant organs.
  • Two classes of cytotoxic drugs broadly employed in pre-operative (neoadjuvant) breast cancer therapy, taxanes and anthracyclines, elicit tumour-derived EVs with enhanced pro-metastatic capacity.
  • Chemotherapy-elicited EVs are enriched in annexin A6 (ANXA6), a Ca2+-dependent protein that promotes NF-ĪŗB-dependent endothelial cell activation,Ā Ccl2induction and Ly6C+CCR2+Ā monocyte expansion in the pulmonary pre-metastatic niche to facilitate the establishment of lung metastasis.

Donā€™t blame yourself if you donā€™t understand what these researchers are talking about. You and me are just laymen — how are we to understand such scientific language? Moreover, some of us donā€™t read English!Ā  How to understand if you only learn your native language in school? Such is our world today.

Let me try to explain what these researchers are trying to tell us by reproducing what others wrote about this particular research results. Perhaps it is easier to understand if it is written in layman’s language.

On 1 January 2019, the Science Daily posted this article, Tumors backfire on chemotherapy. Ā https://www.sciencedaily.com/releases/2019/01/190101094531.htm. Ā There is another article in the Daily Mail, UK – Ā Ā Chemotherapy may cause breast cancer to SPREAD: Two commonly used drugs encourage the disease to develop in the lungs. https://www.dailymail.co.uk/health/article-6542277/Chemotherapy-cause-breast-cancer-SPREAD.html

If you have breast cancer, chemotherapy is often given before surgery. This is called neoadjuvant therapy. The idea in this case is Ā to shrink the tumour and make Ā it easier to remove. Or the chemotherapy is given to “weaken” the cancer. After chemo, the patientā€™s remaining tumor is removed by surgery.

Unfortunately, the treatment does not always shrink the tumour. If the growth resistsĀ neoadjuvant therapy, the cancer is more likely to spread to other parts of the body.

Basically these are what can happen when patients undergo chemotherapy:

  • The commonly prescribed chemo drugs: paclitaxel (or Taxol) and doxorubicin (or Adriamycin) cause breast tumours to release small fluid-filled sacs called exosomes.
  • Chemo-treated tumours makes exosomes that contain a protein called annexin-A6. Annexin-A6 is not found in sacs released from untreated tumours.
  • Once released from tumours, exosomes circulate in the blood until they reach the lungs.
  • They then give out annexin-A6, which stimulates lung cells to release another protein called CCL2.
  • CCL2 then attracts immune cells called monocytes, which fight certain infections and help other cells remove dead or damaged tissue.
  • This immune reaction can be dangerous, because those monocytes can facilitate the survival and growth of cancerous cells in the lung, which is one of the initial steps in metastasis.

Is this the only research showing the chemotherapy spreads cancer? NO – there are many more researchers in the US who have also reported the same message — chemotherapy spreads cancer!

On 6 August 2012, researchers at the Fred Hutchinson Cancer Research Center in Seattle, USA, published their research results inĀ Nature Medicine. https://www.nature.com/articles/nm.2890. These are what they said:

  • Cancer cells inside the body live in a very complex environment or neighborhood. Where the tumorcell resides and who its neighbors are influence its response and resistance to chemotherapy.
  • In the laboratory, you can “cure” almost any cancer — you just give a huge dose of toxic chemo-drug to the cancer cells in the petri dish and the cancer cells are destroyed. But you can’t do that to patients, because the high dose would not only kill cancer cells but also healthy cells. The dose you would need to give the patient to wipe out the cancer would also kill the patient. So in real life, if you want to kill all cancer cells, you can also kill the patient at the same time!
  • So chemo treatment of common solid tumors has to be given as smaller doses paced out in cycles, to give healthy cells time to recover in the intervals. But the drawback is that this approach may not kill all the cancer cells. Those cancer cells that survive can become resistant to subsequent cycles of the chemotherapy.
  • Normal, non-cancerous cell, the fibroblast, that lives near cancer tumors are important for healing wounds and producing When their DNA is damaged, by chemotherapy, fibroblasts can release a broad range of compounds that stimulate cell growth. So you see, in the process of trying to kill cancer cells, chemotherapy may also spur healthy cells in the neighbourhood to release a compound that stimulates cancer growth, eventually leading to treatment resistance.
  • The researchers examined cancer cells from prostate, breast andovarian cancer patients who had been treated with chemotherapy. They found thatĀ when the DNA of fibroblasts near the tumor is damaged by chemotherapy, they start producing a protein called WNT16B in the microenvironment of the tumor.
  • When the protein reaches a high enough level, sometimes increased by thirty-fold. This protein, WNT16B, when secreted, would interact with nearby tumour cells and cause them to grow, invade, and importantly, resist subsequent chemotherapy.

Read these articles:

  1. Can chemotherapy before surgery fuel breast cancer metastasis? https://www.facingourrisk.org/XRAYS/neoadjuvant-chemotherapy-and-metastasis

2. Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism. https://www.ncbi.nlm.nih.gov/pubmed/28679654

3. Chemotherapy could cause cancer to SPREAD and grow back even more aggressive, new study claims

https://www.dailymail.co.uk/health/article-4669152/Chemotherapy-cause-cancer-SPREAD-new-study-says.html

  1. Can chemotherapy before surgery fuel breast cancer metastasis?

https://www.facingourrisk.org/XRAYS/neoadjuvant-chemotherapy-and-metastasis

Scientists at New York’s Albert Einstein College of Medicine, US,Ā  have found evidence that chemotherapy is only a short-term solutionĀ  and can be dangerous. In their study they investigated chemotherapy-induced cancer cell dissemination in breast cancer.

  • While chemotherapy may shrink the tumors, chemotherapy could causecancerĀ to spread and become more deadly.
  • And once cancer spreads to other organs it becomes almost impossible to treat and is often fatal.
  • Three standard chemo-drugs used inĀ neoadjuvantĀ treatment for breast cancer are: paclitaxel (Taxol), doxorubicin (Andriamycin) and cyclophosphamide. They are shown to increase the number of microscopic structures in breast tumorsĀ called tumor microenvironment of metastasis (TMEM), as well as the number of tumor cells circulating in the blood.

How chemo spreads cancer: Scientists believe that in order forĀ metastasisĀ to occur, three types of cells must come in close contact with each other on a blood vessel wall:

  1. tumor cells, that produce high levels of a specific protein.
  2. immune cells called macrophage, and
  3. endothelial cells (cells which line organs such as blood vessels).

These spots, called “tumor microenvironments of metastasisā€ or ā€œTMEMsā€ are found on blood vessels within tumors.

To enable the cancer cells to spread, the macrophages in a TMEMĀ loosen the normally tight connectionĀ that exists between endothelial cells, creating a temporary opening in the wall of a blood vessel for the tumor cell to squeeze through and enter the bloodstream, facilitating its spread to other parts of the body.

Watch thisĀ video. Hopefully it canĀ  help you better understand the complicated process. https://www.youtube.com/embed/IvyJKrx5Xmw?feature=plcp&rel=0&showinfo=0&autoplay=1

This article, Is an anticancer drug helping cancer to spread? https://www.medicalnewstoday.com/articles/318846#1

reported the work ofĀ  another group of scientists at the Ohio State University (OSU) led by Tsonwin Hai, a professor of biological chemistry and pharmacology at OSU. They studied the effects of the commonly used chemo-drug paclitaxelĀ (Taxol) on the spread of Ā breast cancer cells to the lungs. Taxol is also commonly used as a frontline medication in treating ovarian andĀ lung cancer (besides breast cancer).

How a chemo drug can help cancer spread from the breast to the lungs? You can get the answers by reading these two articles: https://www.eurekalert.org/pub_releases/2017-08/osu-hac080417.php, https://www.medicalnewstoday.com/articles/318846.php#1

  • Paclitaxel may activate Atf3 (Activating Transcription Factor 3) gene: In those who had received chemotherapy, the geneĀ Atf3is overexpressed, compared with patients who were not administered chemotherapy. ATF3 is overexpressed in a large fraction of various cancers including solid tumors in theĀ breast,Ā lungs,Ā pancreas, andĀ colon. ATF3 is hyperactivated in most cells in Hodgkin’s disease. Overexpression of ATF3 in cancer cells have been proposed to promote proliferation and inhibit cell death.
  • According to the OSU researches, the findings suggest that paclitaxel may have a carcinogenic effect by activating this gene. This gene seems to do two things at once:
  1. essentially help distribute the ‘seeds’ (cancer cells)- increasing “the abundance of theĀ tumormicroenvironment of metastasis, andĀ 
  2. fertilize the ‘soil’ (the lung – by improving “the tissue microenvironment (the ‘soil’) for cancer cells (the ‘seeds’) to thrive” at the level of the metastatic lung.Ā 

These changes, include increased inflammatory monocytes and reduced cytotoxicity.

Prof. Hai says: What is surprising to us is the multitude of pro-cancer effects that paclitaxel has! It not only enhances the escape of cancer cells from the primary tumor but also facilitates the preparation of distant sites (lung in our case) in such ways that when the cancer cells arrive, they can set up shop and grow.

Chemotherapy is ‘a double-edged sword: Paclitaxel seems to set off a molecular chain reaction, the end result of which is the creation of a cancer cell-friendly environment in the lungs. Prof. Hai ventures a possible explanation for the study’s findings. She says, I think it’s an active process – a biological change in which the cancer cells are beckoned to escape into the blood – rather than a passive process in which the cancer cells get into the bloodstream because of leaky vessels.

Summary

  • Researchers found that the use of chemotherapy — extremely toxic class of drugs — can trigger the onset of new tumors in other parts of the body.
  • Chemotherapy drugs in breast cancer results in production of specific proteins. These circulate in the blood and, upon reaching the lungs, cause the release of further proteins and immune cells that can facilitate the development of metastatic cancer cells.
  • It is like, chemo makes the cancer tumor produce more seeds. These seeds are then carried away to other parts of the body. The chemo also makes the soil so fertile and conducive for the seeds to grow!

Why condone and still “selling” such therapy?

  • Through its continued sale and promotion of toxic chemotherapy drugs for cancer, the pharmaceutical industry is thus ensuring that, far from eradicating the disease, it continues to exist.
  • Small wonder, therefore, that the size of the global oncology market is expected to reach an eye-watering $200 billion annually by the year 2022.
  • The World Health Organization estimates that cancer is now responsible for 9.6 million deaths per year. Breast cancer and lung cancer are the most common forms of the disease, with each seeing over 2 million cases per year.
  • The total annual economic cost of cancer is equally startling, amounting to more than $1 trillion each year. Not only is there no sign of this decreasing, but with the price of some new so-called monoclonal antibodies or biosimilar molecules for cancer now reaching $700,000 per patient per year.

Cancer Drugs Are The Most Profitable For Big Pharma

https://www.dr-rath-foundation.org/2020/02/cancer-drugs-are-the-most-profitable-for-big-pharma/

Drugs for cancer have been the largest business sector of the global pharmaceutical industry for several years now. This is the real reason why cancer still exists.

With annual revenues from the disease exceeding $123 billion a year, drug companies have no interest in preventing the disease. Instead, they prefer to profit from it by selling patented chemical treatments that donā€™t address its primary cause.

For more information you can read our previous articles

Chemotherapy Spreads Cancer and Makes It More Aggressive: Articles From theĀ Internet

Compiled by Yeong Sek Yee & Khadijah Shaari Ā 

https://cancercaremalaysia.com/2013/05/14/chemotherapy-spreads-cancer-and-make-it-more-aggressive-articles-from-the-internet/

Chemotherapy SPREADS and MAKES cancer moreĀ AGGRESSIVE

https://cancercaremalaysia.com/2013/03/09/chemotherapy-spreads-and-makes-cancer-more-aggressive/

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