Lung Cancer: The Meaningless Decrease and Increase of Tumour Markers After Chemotherapy

HK (S97) is a 57-year-old man from Indonesia. Blood test showed that his CA 19.9 was elevated.  A CT scan on 15 March 2011 in Singapore revealed a small right pleural effusion and small nodules in his right lung.

A PET scan done on 17 March 2011 indicated:

  1. Hypermetabolic primary tumour at the right lung apex.
  2. Smaller subcentimeter nodules (below the resolution of PET) in the right lung, suspicious for intrapulmonary metastases.
  3. Right pleural effusion with multiple FDG-avid pleural nodules.
  4. FDG-avid left supraclavicular, subcarinal and right paratracheal nodes, suspicious for nodal involvement.

HK underwent chemotherapy as below:

Date

Procedure

CEA

CA 19.9

19 March 2011 Biopsy at a hospital in Kuala Lumpur.    
22 March 2011 Lung cancer confirmed.    
24 March 2011 Chemo – first cycle, day 1 – Gemcitabine + Cisplatin    
30 March 2011 Chemo – first cycle, second injection 12Apr 11 = 85.5 12Apr 11 = 435.9
20 April 2011 Chemo – second cycle, day 1 – Gemcitabine + Cisplatin    
26 April 2011 Chemo – second cycle, second injection    
28 April to 1 May 2011 Fevers  < 38 C, admitted to hospital    
11 May  2011 Chemo – third cycle, day 1 – Gemcitabine + Cisplatin 11May11 = 123.5 11May11 = 291.6
18 May 2011 Chemo – third  cycle, second injection    
31 May 2011 PET scan – results showed improvement 30May11 = 90.5 30May11= 220.3
1 June 2011 Chemo – fourth cycle, day 1 – Gemcitabine + Cisplatin    
8 June 2011 Chemo – fourth  cycle, second injection    
22 June 2011 Chemo – fifth  cycle, day 1 – Gemcitabine + Cisplatin    
29 June 2011 Chemo – fifth cycle, second injection    
13 July 2011 Chemo delayed due to lack of blood    
20 July 2011 Chemo – sixth cycle, day 1 – Gemcitabine + Cisplatin    
27 July 2011 Chemo – sixth cycle, second injection    
11 August 2011 PET scan – results showed no changes or further improvements 10Aug11 = 64.2 10Aug11 = 164.8
13 August to 17 Nov. 2011 Three months on Tarceva – Rashes in the face and legs. 14 Sep11 = 130.3

12 Oct 11 = 217.7

14 Sep11 = 85.7

12 Oct 11= 114.1

17 November 2011 PET scan – results showed cancer  was more aggressive 16Nov 11 = 523.0 16Nov11 = 438.2
26 November 2011 Chemo – first cycle of Alimta    
16 December 2011 Chemo – second cycle of Alimta 4 Jan 12  = 666.5 4 Jan 12 = 4,422.0
5 Jan12  to

1 Feb.12

Chinese herbs    
3 February 2012 Started on CA Care herbs  – Caspsule A + B, Lung 1 and Lung 2, Pain, Liver Tea 1 Feb. 2012

=737.5

1 Feb. 2012

= 3,917.0

  While on CA Care’s herbs 10 Mar 2012

 = 629.8

10 Mar 2012

= 3,609.0

 

Comments

Study carefully the rise and fall of his CEA. From 85.5 it increased to 123.5 and then decreased to 64.2 after which it started to climb to 130.3 to 737.5. After CA Care’s herbs it went down to 629.8.

Study carefully the rise and fall of his 19.9. It started with 435.9. With chemotherapy it decreased to 291.6, 164.8 and eventually 85.7. However with more treatment the CA 19.9 started to increase to 114.1, 438.2 and eventually 4,422.0. After CA Care’s herbs it went down to 3,609.0.

When the CEA or CA 19.9 went down after chemotherapy, patient and his family were happy and the doctor surely is similarly happy and “believes” that the treatment has done the trick. But there is no cause for celebration because the decrease of CEA and CA 19.9 are just meaningless. It happens often – only that those concerned never want to see reality. They want to believe that chemotherapy is going to cure their cancer!

In the case of HK above, again I say, the increase and decrease of his tumour markers is meaningless. At the end of the day, this is what his lung looked like. No use and no cure.

 

Increase or decrease of CEA and CA 19.9 after chemotherapy is meaningless when the end results of the treatment are like these!

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